South Africa: Bushmans Kloof Wilderness Reserve

Photograph courtesy Bushmans Kloof Wilderness Reserve & Wellness Retreat

Each September, the UNESCO-protected Cape Floral Region bursts into living color with some of the greatest concentrations of floral species in the world. Bushmans Kloof, a century-old homestead turned nature reserve, cares for 18,532 acres of this rare habitat—home to endangered Cape mountain zebras and archaeological sites that include 10,000-year-old San rock paintings. “We are dedicated to Bushmans Kloof’s enduring legacy, to help protect and preserve its precious heritage through ecotourism, conservation programs, and community benefit projects,” says South African-born Toni Tollman, who oversees the reserve on behalf of her family. Sixteen lavish rooms and a private family villa serve as the base camp for daily outings or unwinding fireside (above) with a glass of the Cape’s finest vintages.16 rooms; from $420, including full board.

Indonesia: Misool Eco Resort

Photograph courtesy Misool Eco Resort

This eco-hideaway, consisting of 13 breezy bungalows handcrafted out of salvaged driftwood, turns the old cliché that the journey matters more than the destination on its head: It’s not easy to reach this remote outpost in Indonesia’s Raja Ampat archipelago, but being there makes it all worthwhile. Located at the center of Southeast Asia’s famed Coral Triangle, Misool provides front-row access to an underwater world teeming with marine life (above)—there are more kinds of fish and coral here than bird species in the Amazon. Local village visits and paddling across the baby blue waters are also options, but for diving and snorkeling aficionados, this is a trip of a lifetime. 13 rooms; from $5,466 for 7 nights (minimum stay), including full board.